Amoxicillin Drug Interactions

Probenecid, birth control pills, and some antibiotics may interact with amoxicillin. Drug interactions could decrease the effectiveness of the medications or increase your risk for side effects (including skin rashes and other allergic reactions). To reduce your risk of developing potentially negative amoxicillin interactions, make sure to tell your healthcare provider about all other medicines you are taking.

Amoxicillin Drug Information

An Overview of Interactions With Amoxicillin

Amoxicillin (Amoxil^®, Moxatag^™) can potentially interact with a few other medications. Some of these medicines that may lead to amoxicillin interactions include:

Allopurinol (Aloprim™, Zyloprim^®)
Birth control pills
Certain other antibiotics, such as:

Chloramphenicol
Macrolides, such as azithromycin (Zithromax^®), clarithromycin (Biaxin^®), or erythromycin (Ery-Tab^®)
Sulfonamides ("sulfa drugs"), including sulfadiazine, sulfadoxine (Fansidar^®), sulfamethoxazole (Bactrim^®, Septra^®), and sulfisoxazole (Gantrisin^®)
Tetracyclines, such as doxycycline (Periostat^®, Vibramycin^®), minocycline (Minocin^®), and tetracycline (Sumycin^®)

Methotrexate (Rheumatrex^®, Trexall™)
Oral typhoid vaccine
Probenecid (Benuryl™).

Amoxicillin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when amoxicillin is combined with any of the drugs listed above.

(Amoxicillin Drug Interactions Continued: Page 2)