Augmentin Drug Interactions
If birth control pills, methotrexate, or an oral typhoid vaccine is taken in conjunction with Augmentin, drug interactions could develop. These negative interactions may increase your risk of side effects, reduce the effectiveness of the medications, or lead to high drug levels in your system. To help prevent Augmentin drug interactions, talk to your healthcare provider before taking any other medicines.
Augmentin® (amoxicillin and clavulanate potassium) can potentially interact with several other medicines. Some of the medicines that may lead to Augmentin drug interactions include:
- Allopurinol (Aloprim™, Zyloprim®)
- Methotrexate (Rheumatrex®, Trexall™)
- Oral anticoagulants (“blood thinners”), such as warfarin (Coumadin®, Jantoven®)
- Oral contraceptives (birth control pills)
- Oral typhoid vaccine
- Probenecid (Benuryl™).
The following sections explain in detail the potentially negative interactions that can occur when Augmentin is combined with any of the drugs listed above.
Combining allopurinol with antibiotics similar to Augmentin increases the risk of skin rashes. It is not known whether this is also true with Augmentin.
Penicillin-type antibiotics (including Augmentin) may decrease the body's ability to remove methotrexate, leading to high blood levels of methotrexate in the blood. Your healthcare provider may need to monitor your more closely to prevent this interaction from occurring.
There have been rare reports of Augmentin interacting with oral anticoagulants such as warfarin, causing a high international normalized ratio (INR), which may indicate an increased risk for bleeding. Your healthcare provider may need to monitor you more closely if you must take these two medications together.