Azactam and Pregnancy
As a pregnancy Category B medicine, Azactam (aztreonam injection) is generally considered safe for use during pregnancy. In animal studies, the medication did not appear to cause birth defects or other problems when given in high doses. However, it's still important to discuss the benefits and risks with your healthcare provider before starting treatment.
Azactam® (aztreonam injection) is a prescription antibiotic medication used to treat a variety of infections caused by certain bacteria. It is generally considered safe for use during pregnancy.
The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Azactam is classified as a pregnancy Category B medication.
Pregnancy Category B is given to medicines that have not been adequately studied in pregnant humans but do not appear to cause harm to the fetus in animal studies. Medications that have been shown to be safe for use in pregnancy in humans but have caused problems in laboratory animals are also given a Category B rating.
Azactam has not been adequately studied in pregnant women. It has been shown to cross the placenta and enter into an unborn child's bloodstream.
In animal studies, the drug did not cause birth defects or other problems when given to pregnant rats and rabbits, even in doses that were as high as 15 times the maximum recommended human dose. This is the reason Azactam is classified as a pregnancy Category B medication.
However, it is important to note that animals do not always respond to medicines in the same way that humans do. Therefore, a pregnancy Category B medicine should be given to a pregnant woman only if her healthcare provider believes that the benefits to the woman outweigh any possible risks to her unborn child. In many cases, the risks of not treating an infection during pregnancy would be greater than the possible risks of using this medication.