Taking Bactrim With Other Drugs

Bactrim Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Bactrim is combined with any of the drugs listed above.
 
Angiotensin-Converting Enzyme Inhibitors (ACE Inhibitors)
Taking Bactrim with an ACE inhibitor may increase the risk of high potassium levels in the blood (hyperkalemia), which can be dangerous. Check with your healthcare provider before combining Bactrim with an ACE inhibitor.
 
Amantadine
Bactrim might increase the risk of confusion due to amantadine. Be sure to let your healthcare provider know if you experience confusion while taking these two medications.
 
Angiotensin II Receptor Blockers (ARBs)
Taking Bactrim with an ARB may increase the risk of high potassium levels in the blood (hyperkalemia), which can be dangerous. Check with your healthcare provider before combining Bactrim with an ARB medication.
 
Cyclosporine
Taking cyclosporine with Bactrim may make cyclosporine less effective (due to lower blood levels of cyclosporine) and may increase the risk of kidney damage due to cyclosporine. Your healthcare provider may need to monitor your cyclosporine levels and your kidney function if you take these medications together.
 
Digoxin
Bactrim may increase the level of digoxin in your blood, perhaps increasing your chance for side effects of digoxin. Your healthcare provider may want to monitor the level of digoxin in your blood.
 
Dofetilide
Bactrim increases the level of dofetilide in the blood, increasing the risk of dangerous side effects of dofetilide. These two medications should not be combined.
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