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Bactrim Drug Interactions
When ACE inhibitors, oral diabetes medications, or thiazide diuretics are taken in combination with Bactrim, drug interactions could occur. Some interactions may decrease the effectiveness of the medicines, while others can increase the risk of dangerous side effects. Since many medications can cause negative Bactrim interactions, it is important to tell your healthcare provider about all other drugs you are taking before starting the antibiotic.
Bactrim® (sulfamethoxazole/trimethoprim) can potentially interact with many medications, too many to list entirely in this article. Some (but not all) of these medicines that may lead to Bactrim drug interactions include:
- Angiotensin-converting enzyme inhibitors (ACE inhibitors), including:
- Benazepril (Lotensin®), benazepril-hydrochlorothiazide (Lotensin® HCT), or benazepril-amlodipine (Lotrel®)
- Captopril (Capoten®) or captopril-hydrochlorothiazide (Capozide®)
- Enalapril (Vasotec®), enalapril-hydrochlorothiazide (Vaseretic®), or enalapril-felodipine (Lexxel®)
- Fosinopril (Monopril®) or fosinopril-hydrochlorothiazide (Monopril-HCT®)
- Lisinopril (Prinivil®, Zestril®) or lisinopril-hydrochlorothiazide (Prinzide®, Zestoretic®)
- Quinapril (Accupril®) or quinapril-hydrochlorothiazide (Accuretic®, Quinaretic®)
- Ramipril (Altace®)
- Amantadine (Symmetrel®)
- Angiotensin II receptor blockers (ARBs), such as:
- Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
- Candesartan (Atacand®) or candesartan-hydrochlorothiazide (Atacand HCT®)
- Eprosartan (Teveten®) or eprosartan-hydrochlorothiazide (Teveten® HCT)
- Irbesartan (Avapro®) or irbesartan-hydrochlorothiazide (Avalide®)
- Losartan (Cozaar®) or losartan-hydrochlorothiazide (Hyzaar®)
- Olmesartan (Benicar®), olmesartan-hydrochlorothiazide (Benicar HCT®), or amlodipine and olmesartan (AZOR™)
- Telmisartan (Micardis®) or telmisartan-hydrochlorothiazide (Micardis® HCT)
- Valsartan (Diovan®) or valsartan-hydrochlorothiazide (Diovan HCT®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Digoxin (Digitek®, Lanoxin®)
- Dofetilide (Tikosyn®)
- Indomethacin (Indocin®)
- Leucovorin or levoleucovorin (Fusilev™)
- Methotrexate (Rheumatrex®)
- Oral diabetes medications
- Oral typhoid vaccine
- Phenytoin (Dilantin®, Phenytek®)
- Procainamide (Procanbid®)
- Pyrimethamine (Daraprim®)
- Thiazide diuretics, such as:
- Chlorothiazide (Diuril®)
- Chlorthalidone (Thalitone®)
- Hydrochlorothiazide (Esidrix®, HydroDIURIL®, Microzide®, Oretic®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD