Drug Interactions With Cefazolin

Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while using cefazolin (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
Oral Typhoid Vaccine
Like other antibiotics, cefazolin may decrease the effectiveness of the oral typhoid vaccine. If you have received cefazolin recently or are currently using it, your oral typhoid vaccine may need to be postponed for at least a day after receiving the drug.
Phenytoin or Phosphenytoin
Cefazolin may increase blood levels of phenytoin or phosphenytoin. Your healthcare provider might want to monitor your blood levels of these drugs and adjust your phenytoin or phosphenytoin dosage as necessary.
Probenecid can decrease the body's ability to remove cefazolin from the blood, potentially leading to high cefazolin blood levels. Talk with your healthcare provider before using these medications together. In general, people taking probenecid should receive no more than 6 grams of cefazolin each day.
There have been reports that cephalosporin antibiotics, including cefazolin, can increase the anticoagulant effects of warfarin. If you are using warfarin, close monitoring will be necessary during cefazolin treatment and for a while after treatment ends. Your warfarin dosage may need to be temporarily adjusted.

Cefazolin Medication Information

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