Cefotan Warnings and Precautions

If you have an allergy to penicillin, you may also be allergic to Cefotan. Some people may also have an increased risk for developing problems like potentially life-threatening diarrhea, serious allergic reactions, and other dangerous complications. Other important warnings for using Cefotan safely include precautions against potential drug interactions and potential risks for women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving Cefotan® (cefotetan) if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • An allergy to cephalosporin or penicillin antibiotics
  • Any other allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Cefotan

Some warnings and precautions to be aware of prior to using this medication include the following:
  • Cefotan contains an antibiotic that belongs to the cephalosporin group of antibiotics, which are related to penicillin antibiotics. Some people who are allergic to penicillin will also be allergic to Cefotan. An allergic reaction can be quite dangerous. Let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as:
    • A rash
    • Itching
    • Hives
    • Wheezing
    • Swelling of the mouth or lips
    • Difficulty breathing.
  • Cephalosporins are associated with a potentially serious condition known as hemolytic anemia. Cefotan seems more likely to cause this problem, compared with most other cephalosporins. Let your healthcare provider know if you develop any signs or symptoms of this problem, such as:  
    • Pale skin
    • Fatigue
    • Dizziness.
  • Make sure your healthcare provider knows if you have kidney disease, as the kidneys excrete Cefotan from the body. If your kidneys are not functioning well, you will need a lower and/or less-frequent Cefotan dosage.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of Cefotan, bloody or watery diarrhea may be a sign of a serious reaction to Cefotan that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop using Cefotan and can be life-threatening.
  • Antibiotics, including Cefotan, can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) during treatment.
  • Alert your healthcare provider right away if you develop any neurological symptoms, such as seizures, confusion, hallucinations, or coma. Problems such as these may occur when Cefotan dosages are too high.
  • Cefotan should not be used to treat viruses, such as the common cold or the flu. This drug is completely ineffective for treating viruses, and such use can lead to bacterial resistance.
  • Cefotan may react with other medications (see Cefotan Drug Interactions).
  • Cefotan is a pregnancy Category B medication. This means it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using Cefotan during pregnancy (see Cefotan and Pregnancy for more information).
  • Cefotan passes through breast milk. Therefore, if you are breastfeeding or plan to start, talk to your healthcare provider about using Cefotan (see Cefotan and Breastfeeding for more information).

Cefotan Antibiotic Information

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