Drug Interactions With Cefotaxime

Problems may occur if you combine cefotaxime with other antibiotics, birth control pills, or other products. Drug interactions such as these may result in complications, such as kidney damage, unintentional pregnancy, and various side effects. To help minimize the risk for adverse reactions, tell your healthcare provider about all vitamins, supplements, and prescription or nonprescription drugs you are taking.

An Overview of Cefotaxime Interactions

Cefotaxime (Claforan®) may react with a few other products. Some of the drugs that can interact with cefotaxime include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

More Detail on Drug Interactions With Cefotaxime

The following sections explain in detail the potentially negative interactions that can occur when cefotaxime is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining cefotaxime with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while using cefotaxime (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.

Cefotaxime Antibiotic Information

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