Common and Rare Reactions to Cefuroxime Axetil

Common Side Effects of Cefuroxime Axetil

Cefuroxime axetil has been thoroughly studied in clinical trials. Based on information from these trials, the most common side effects of cefuroxime axetil include:
  • Diarrhea or loose stools -- in up to 10.6 percent of people
  • Nausea and vomiting -- up to 6.8 percent
  • Vaginitis (vaginal inflammation or infection) -- up to 5.4 percent
  • Dislike of taste (for the oral suspension form) -- up to 5 percent
  • Diaper rash -- up to 3.4 percent.
Changes in certain laboratory tests (such as an increase in liver enzymes) were also commonly seen (in about 1 percent of people). These changes were temporary and probably did not indicate any real problems.
A specific type of reaction known as the Jarisch-Herxheimer reaction was seen in up to 5.6 percent of people who were given cefuroxime axetil to treat Lyme disease. This reaction is thought to be the result of toxins released from the death of a large number of bacteria. This reaction is not expected to occur when taking cefuroxime axetil for more typical uses (such as to treat ear infections or strep throat).

Rare Side Effects

There are a number of side effects that were reported rarely in clinical trials (meaning they occurred in less than 1 percent of people). For these side effects, it can be difficult to tell if the problems were actually caused by the medication or by other related or unrelated factors.
These rare cefuroxime axetil side effects included but were not limited to:
  • Abdominal pain (stomach pain) and cramping
  • Gas
  • Headaches
  • Chills
  • Loss of appetite
  • Thirst
  • Mouth sores
  • Indigestion or heartburn
  • Dizziness
  • Drowsiness.
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