Side Effects of Ciprofloxacin/Hydrocortisone

Although most people have no problems with ciprofloxacin/hydrochloride, side effects are possible. In clinical studies, the most commonly reported reaction was headache. Fortunately, side effects are generally mild and easily treated. However, if you experience anything that "just does not seem right," especially wheezing, unexplained swelling, and trouble breathing, contact your healthcare provider.

An Introduction to Ciprofloxacin/Hydrocortisone Side Effects

Just like any medicine, ciprofloxacin/hydrocortisone (Cipro® HC) can cause side effects. However, not everyone who uses the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects of ciprofloxacin/hydrocortisone. Your healthcare provider can discuss a more complete list with you.)

Side Effects of Ciprofloxacin/Hydrocortisone to Report

Potentially serious ciprofloxacin/hydrocortisone side effects that should be reported to your healthcare provider immediately include:
  • Severe or persistent ear irritation or pain that does not go away or that gets worse with repeated ciprofloxacin/hydrocortisone use


  • Signs of a fungal or yeast infection, such as itchy, flaky, or red skin or white patches in your mouth or throat


  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Hives
    • Itching
    • Unexplained swelling of the mouth or throat
    • Wheezing or difficulty breathing or swallowing.
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Ciprofloxacin/Hydrocortisone Drug Information

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