Ciprofloxacin Drug Interactions
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The following sections explain in detail the potentially negative interactions that can occur when ciprofloxacin is combined with any of the drugs listed above.
Aluminum, Calcium, or Magnesium Antacids
Aluminum, calcium, and magnesium can bind to ciprofloxacin in the digestive tract, preventing it from being absorbed into the bloodstream. You should take your ciprofloxacin dosage at least two hours before or six hours after taking any products that contain aluminum, calcium, or magnesium.
Ciprofloxacin may reduce the body's ability to clear caffeine, potentially increasing caffeine's effects. Therefore, it may be a good idea to limit your caffeine intake while taking ciprofloxacin. Keep in mind that many food and beverages contain caffeine, such as coffee, tea, and chocolate.
Corticosteroids seem to increase the risk of tendon problems, including tendon rupture, when taken with ciprofloxacin. Older adults appear to be at an even higher risk for this reaction. If you take ciprofloxacin with a corticosteroid, make sure to watch for any signs of tendon problems, such as tendon or joint pain or tenderness.
Some forms of didanosine can bind to ciprofloxacin in the digestive tract, preventing it from being absorbed into the bloodstream. You should take your ciprofloxacin dose at least two hours before or six hours after taking didanosine. Not all forms of didanosine interact with ciprofloxacin, so make sure to ask your pharmacist about this possible interaction with your particular didanosine product.
Ciprofloxacin may increase the levels of erlotinib in your body, increasing your risk for side effects. If you take these medications together, be watchful for signs of severe erlotinib reactions, including severe diarrhea and skin reactions. Your healthcare provider may need to decrease your erlotinib dosage.