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Ciprofloxacin Drug Interactions
P-glycoprotein Inhibitors
P-glycoprotein (Pgp) is a protein found in the body. One of its roles is to help remove substances such as medications from the body. Ciprofloxacin is one of the drugs partly removed from the body by Pgp. Medications known as Pgp inhibitors decrease the action of Pgp. Thus, taking ciprofloxacin with a Pgp inhibitor may increase the amount of ciprofloxacin in your blood, potentially increasing your risk for side effects.
Your healthcare provider may need to monitor you more closely if you take ciprofloxacin with a Pgp inhibitor.
Pentoxifylline
Ciprofloxacin may increase the amount of pentoxifylline in your body, potentially increasing your risk for pentoxifylline side effects, such as headaches. If you are taking these medications together, make sure to let your healthcare provider know if you develop bothersome headaches.
Phenytoin
Ciprofloxacin may decrease or increase the amount of phenytoin in your body, potentially making phenytoin less effective or increasing your risk for side effects. You may also have an increased risk for seizures. Talk to your healthcare provider about this interaction if you take phenytoin.
Probenecid
Taking probenecid with ciprofloxacin may increase the amount of ciprofloxacin in your blood, increasing your risk for side effects. Be especially watchful for ciprofloxacin side effects if you take these medications together.
Quinapril
Quinapril can bind to ciprofloxacin in the digestive tract, preventing it from being absorbed into the bloodstream. Separate your ciprofloxacin and quinapril doses by at least two hours to help minimize the chance of this interaction.
Ropinirole
Ciprofloxacin may increase the amount of ropinirole in your body, increasing your risk for side effects. Your healthcare provider may choose to monitor you more closely for side effects of ropinirole if you take these medications together.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD