Precautions and Warnings With Cleocin

Cleocin can disrupt the normal bacteria in the digestive tract, allowing undesirable bacteria to overgrow. Other safety warnings and precautions with Cleocin apply to people who have certain allergies and women who are pregnant or breastfeeding. You may not be able to take this antibiotic if you have certain health conditions, such as kidney disease, liver disease, or colitis.

What Should I Tell My Healthcare Provider?

Prior to taking Cleocin® (clindamycin), tell your healthcare provider if you have:
  • Frequent yeast infections
  • Kidney disease, such as kidney failure (renal failure)
  • Liver disease, such as cirrhosis, liver failure, or hepatitis
  • Colitis
  • Any allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Cleocin Warnings and Precautions

Some precautions and warnings to be aware of prior to taking Cleocin include the following:
  • Cleocin should not be used to treat meningitis, as it does not adequately cross to the cerebrospinal fluid.
  • Antibiotics can disrupt the normal bacteria in the digestive tract, allowing undesirable bacteria to overgrow. A serious problem known as pseudomembranous colitis may result and can occur while you are taking Cleocin or even weeks later.
Make sure to watch for signs of this problem, which can lead to life-threatening complications, such as bloody diarrhea or severe diarrhea. Mild, short-term diarrhea is a common side effect of many antibiotics and is usually not a cause for concern.
  • While pseudomembranous colitis is most common with oral or IV Cleocin, it is also possible with other forms of the medication that are applied to the skin or inserted vaginally.
  • Cleocin can disrupt the normal bacteria in the vagina, which may lead to yeast infections.
  • If long-term treatment with this medicine is necessary, your healthcare provider should regularly monitor your kidney and liver health. This is probably only an issue for the oral or injectable forms of the medication.
  • Cleocin can potentially interact with other medications (see Drug Interactions With Cleocin).
  • Cleocin is considered a pregnancy Category B medication. This means that it may be safe for use during pregnancy, although the full risks are not known (see Clindamycin and Pregnancy).
  • Cleocin passes through breast milk. Therefore, if you are breastfeeding a child, discuss this with your healthcare provider prior to taking the drug (see Clindamycin and Breastfeeding).
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Cleocin Antibiotic Information

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