Doxycycline Drug Interactions

When certain medications are taken with doxycycline, drug interactions may occur that can result in serious side effects. Examples of drug interactions that may cause the body to metabolize the medicines differently than intended include warfarin, oral contraceptives, and retinoids. Other doxycycline drug interactions can cause reduced effectiveness of one (or both) medicines and increased levels of these drugs in your system.

Doxycycline Drug Interactions: An Introduction

Doxycycline may interact with a number of other medicines. The medications that may lead to doxycycline drug interactions can include but are not limited to:
 
  • Aluminum, calcium, magnesium, or iron products (such as antacids, iron supplements, calcium supplements, laxatives, and multivitamins)
  • Barbiturates, including (but not limited to):
     
    • Amobarbital (Amytal®)
    • Butalbital (Fioricet®, Fiorinal®)
    • Pentobarbital (Nembutal®)
    • Phenobarbital (Luminal®)
    • Secobarbital (Seconal®)
 
 
 
  • Phenytoin (Dilantin®, Phenytek®)
  • Quinapril (Accupril®)
  • Ranolazine (Ranexa®)
  • Retinoids, such as:
     
    • Acitretin (Soriatane®)
    • Bexarotene (Targretin®)
    • Isotretinoin (Accutane®, Amnesteem™, Claravis™, Sotret®)
    • Tretinoin (Atralin™, Avita®, Renova®, Retin-A®, Tretin-X™, Vesanoid®)
    • Tazarotene (Avage™, Tazorac®)
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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