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Doxycycline Drug Interactions
When certain medications are taken with doxycycline, drug interactions may occur that can result in serious side effects. Examples of drug interactions that may cause the body to metabolize the medicines differently than intended include warfarin, oral contraceptives, and retinoids. Other doxycycline drug interactions can cause reduced effectiveness of one (or both) medicines and increased levels of these drugs in your system.
Doxycycline may interact with a number of other medicines. The medications that may lead to doxycycline drug interactions can include but are not limited to:
- Aluminum, calcium, magnesium, or iron products (such as antacids, iron supplements, calcium supplements, laxatives, and multivitamins)
- Barbiturates, including (but not limited to):
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Bile-acid sequestrant cholesterol medications, including:
- Cholestyramine (Prevalite®, Questran®, Questran® Light)
- Colesevelam (WelChol®)
- Colestipol (Colestid®)
- Birth control pills (oral contraceptives)
- Bismuth subsalicylate (Pepto-Bismol®)
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Eplerenone (Inspra™)
- Fentanyl (Abstral®, Actiq®, Duragesic®, Fentora®, Lazanda®, Onsolis®, Subsys®)
- Maraviroc (Selzentry™)
- Oral typhoid vaccine
- Penicillins, such as:
- Amoxicillin (Amoxil®, Moxatag®)
- Amoxicillin and clavulanate potassium (Augmentin®, Augmentin ES-600®, Augmentin XR®)
- Ampicillin
- Ampicillin and sulbactam (Unasyn®)
- Carbenicillin (Geocillin®)
- Dicloxacillin
- Nafcillin
- Oxacillin
- Penicillin (Bicillin® C-R, Bicillin® L-A, Pfizerpen®)
- Piperacillin
- Piperacillin and tazobactam (Zosyn®)
- Ticarcillin and clavulanate potassium (Timentin®)
- Phenytoin (Dilantin®, Phenytek®)
- Quinapril (Accupril®)
- Ranolazine (Ranexa®)
- Retinoids, such as:
- Acitretin (Soriatane®)
- Bexarotene (Targretin®)
- Isotretinoin (Accutane®, Amnesteem™, Claravis™, Sotret®)
- Tretinoin (Atralin™, Avita®, Renova®, Retin-A®, Tretin-X™, Vesanoid®)
- Tazarotene (Avage™, Tazorac®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD