Serious and Rare Reactions to Doxycycline

Serious Doxycycline Side Effects

Some doxycycline side effects can indicate a potentially serious problem. If you experience any of these side effects, stop taking doxycycline and call your healthcare provider. These side effects include but are not limited to:
  • Difficulty swallowing (dysphagia) or severe throat pain
  • Watery diarrhea
  • Severe stomach cramps
  • Bloody stools
  • Unusual headaches
  • Blurred vision
  • Unexplained rash
  • Joint pain
  • Fever
  • Feeling tired
  • Signs of an allergic reaction, such as:


    • An unexplained rash
    • Hives
    • Itching
    • Wheezing
    • Swelling of the mouth or throat
    • Difficulty breathing.

Rare Doxycycline Side Effects

Rare doxycycline side effects occur in less than 1 percent of people taking the drug. Because these side effects are so uncommon, it is difficult to tell whether they are actually caused by the medication or by something else.
Some of these rare side effects include but are not limited to:
  • Allergic reaction
  • Liver damage
  • Vision changes
  • Irritation of the esophagus (esophagitis)
  • Ulcers of the esophagus
  • Increased pressure in the skull (intracranial hypertension)
  • Worsening of systemic lupus erythematosus symptoms (SLE for short or lupus)
  • Increased rate of red blood cell destruction (hemolytic anemia)
  • Reduced amount of platelets in the blood (thrombocytopenia)
  • Tongue swelling (glossitis)
  • Serious intestinal infection (enterocolitis)
  • Vaginal yeast infection.

Doxycycline Antibiotic Information

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