Erythromycin Drug Interactions

If certain benzodiazepines, statins, ED medications, or other drugs are taken with erythromycin, interactions can occur that may be dangerous, even life-threatening. For example, erythromycin should never be taken with ergot medicines because it can increase the risk of ergot toxicity. To minimize your risk of problems, make sure your healthcare provider has a complete list of all drugs you are taking.

Interactions With Erythromycin: An Overview

Erythromycin can potentially interact with a number of other medications. Some of the drugs that may lead to interactions with erythromycin include but are not limited to:
  • Colchicine
  • Digoxin (Digitek®, Lanoxin®)
  • Ergot medications, such as:
    • Bromocriptine (Parlodel®)
    • Dihydroergotamine (Migranal®)
    • Ergonovine
    • Ergotamine (Cafergot®, Ergomar®)
    • Methylergonovine (Methergine®)
    • Pergolide (Permax®)
  • HIV/AIDS medications
  • Phosphodiesterase type 5 inhibitors (PDE5 inhibitors), including:


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