Cimetidine, disulfiram, and certain seizure medications may interact negatively with Flagyl. Interactions may occur if Flagyl is taken with these medicines that may increase your risk of developing side effects or reduce the effectiveness of the medication. To help prevent these potentially serious Flagyl drug interactions, tell your healthcare provider about all other medications you are taking before using the antibiotic.
Flagyl® (metronidazole) can potentially interact with a few other medications. Some of these medicines that may lead to Flagyl interactions include:
- Cimetidine (Tagamet®)
- Disulfiram (Antabuse®)
- Eplerenone (Inspra™)
- Lithium (Eskalith®, Lithobid®)
- Maraviroc (Selzentry™)
- Oral typhoid vaccine
- Ranolazine (Ranexa®)
- Warfarin (Coumadin®, Jantoven®).
Flagyl Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when Flagyl is combined with any of the drugs listed above.