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Floxin Drug Interactions
Several different products, such as insulin, aspirin, corticosteroids, and iron supplements, can cause drug interactions with Floxin. Such reactions may lead to decreased effectiveness of the medications or an increased risk for potentially serious side effects. To avoid these problems, your healthcare provider may choose to adjust your dosages or monitor you more carefully during treatment.
Floxin® (ofloxacin) can potentially interact with many other medicines. Some of the drugs that may lead to Floxin interactions include but are not limited to:
- Aluminum, calcium, or magnesium antacids (Alternagel®, Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
- Aspirin (Bayer®)
- Betaxolol (Kerlone®)
- Caffeine
- Certain antipsychotic medications, such as:
- Asenapine (Saphris®)
- Clozapine (Clozaril®, FazaClo®)
- Olanzapine (Zyprexa®, Symbyax®)
- Pimozide (Orap®)
- Thiothixene (Navane®)
- Trifluoperazine (Stelazine®)
- Clomipramine (Anafranil®)
- Corticosteroids, such as:
- Betamethasone (Celestone®)
- Cortisone
- Dexamethasone (Decadron®)
- Fludrocortisone (Florinef®)
- Hydrocortisone (Cortef®)
- Methylprednisolone (Depo-Medrol®, Medrol®)
- Prednisolone (Ovapred®, Pediapred®)
- Prednisone
- Triamcinolone (Kenalog®, Aristospan®)
- Cyclobenzaprine (Flexeril®, Amrix®)
- Didanosine (Videx®)
- Duloxetine (Cymbalta®)
- Flutamide
- Fluvoxamine (Luvox®, Luvox® CR)
- Guanabenz
- Insulin
- Iron supplements, such as ferrous gluconate and ferrous sulfate
- Medications that cause a certain change in the heart rhythm known as QT prolongation (see QT-Prolonging Medications for a list of such drugs)
- Mirtazapine (Remeron®)
- Mycophenolate (CellCept®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Celecoxib (Celebrex®)
- Diclofenac (Cambia™, Cataflam®, Flector®, Solaraze® Gel, Voltaren®, Voltaren® Gel, Voltaren®-XR, Voltaren Ophthalmic®, Zipsor™)
- Etodolac (Lodine®, Lodine® XL)
- Ibuprofen (Motrin®, Advil®, Nuprin®)
- Indomethacin (Indocin®, Indocin SR®)
- Ketoprofen (Orudis®, Actron®, Oruvail®)
- Ketorolac (Toradol®)
- Meloxicam (Mobic®)
- Nabumetone (Relafen®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Oxaprozin (Daypro®)
- Piroxicam (Feldene®)
- Others (see List of NSAIDs for a more complete list of these drugs)
- Probenecid
- Propranolol (Inderal®, Inderal LA®, InnoPran XL®, also found in Inderide®)
- Quinapril (Accupril®) or quinapril-hydrochlorothiazide (Accuretic®, Quinaretic®)
- Ramelteon (Rozerem®)
- Rasagiline (Azilect®)
- Ropinirole (Requip®) and ropinirole XL (Requip® XL)
- Sevelamer (Renagel®, Renvela®)
- Sucralfate (Carafate®)
- Sulfonylureas (or sulfonylurea combination medications), such as:
- Chlorpropamide (Diabinese®)
- Glimepiride (Amaryl®)
- Glimepiride and pioglitazone (Duetact®)
- Glimepiride and rosiglitazone (Avandaryl®)
- Glipizide (Glucotrol®, Glucotrol XL®)
- Glipizide and metformin (Metaglip®)
- Glyburide (DiaBeta®, Micronase®, Glynase®)
- Glyburide and metformin (Glucovance®)
- Tolazamide (Tolinase®)
- Tolbutamide (Orinase®)
- Theophylline (Uniphyl®, Theochron®, TheoCap®, Theo-24®, Elixophyllin®)
- Tizanidine (Zanaflex®)
- Typhoid vaccine
- Vitamins that contain aluminum, calcium, magnesium, zinc, or iron
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Susan Lakey, PharmD, MPH
Last reviewed by: Kristi Monson, PharmD