Precautions and Warnings With Keflex

Precautions and warnings with Keflex should be reviewed prior to taking the drug. Tell your healthcare provider if you have kidney disease, are pregnant, or are about to have surgery. Precautions and warnings with Keflex also extend to people who are allergic to the drug, to related drugs (like Omnicef and Rocephin), or to any inactive ingredients used in making Keflex.

Keflex: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Keflex® (cephalexin) if you:
  • Have kidney disease or kidney failure.
  • Are pregnant or thinking of becoming pregnant.
  • Are breastfeeding.
  • Will be having surgery.
  • Have any allergies. This includes allergies to Keflex, to other cephalosporins such as Omnicef® (cefdinir) and Rocephin® (ceftriaxone), to penicillin, or to other types of antibiotics.
Also tell your healthcare provider about all medicines you take, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings With Keflex

Precautions and warnings with Keflex people should be aware of before taking it include the following:
  • Keflex can interact with certain medications (see Drug Interactions With Keflex).
  • About 10 percent of people who are allergic to penicillins may also be allergic to Keflex. Therefore, tell your healthcare provider if you are allergic to penicillin. Also, if taking Keflex, let your healthcare provider know if you develop:
    • Any unexplained rash
    • Itchy skin
    • Hives
    • Wheezing
    • Swelling of the throat
    • Difficulty breathing.
  • Keflex is considered a pregnancy Category B medication. This means that it has not been studied in pregnant women. When studied in animals, however, Keflex showed no negative effects on the fetus. If you are taking Keflex and pregnancy occurs, discuss the safety of this drug with your healthcare provider.
  • If you have severe kidney disease, your healthcare provider may give you a lower dose of Keflex than normal or not prescribe this medication at all.
  • If you are nursing, it is known that Keflex passes through breast milk. Therefore, you are recommended to stop nursing while taking it.
  • Many antibiotics, including Keflex, have been known to cause pseudomembranous colitis (severe diarrhea) in some people. Contact your healthcare provider immediately if you experience:
    • Severe, watery diarrhea
    • Blood in your stools
    • Stomach pain
    • Low-grade fever.
  • Some people have been known to experience other infections while taking antibiotics. If you notice any unrelated symptoms, talk to your healthcare provider.
  • Taking Keflex is known to increase the chance of developing vaginal yeast infections.
  • Never take outdated Keflex. Taking any outdated medication may cause serious problems because the intended effects often change after the medicine expires.
A Dose of Reassurance for Parents of Picky Eaters

Keflex Antibiotic

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