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Levaquin Interactions
A number of medications could potentially interfere with Levaquin. Interactions may occur if the antibiotic is taken together with corticosteroids, diabetes medicines, or nonsteroidal anti-inflammatory drugs (NSAIDs), to name a few. Some medicines may prevent Levaquin from being absorbed into the bloodstream. Other Levaquin drug interactions can increase the risk of certain complications, including tendon rupture, changes in blood sugar, and seizures.
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Levaquin® (levofloxacin) can potentially interact with a few other medications. Some of these medicines that may lead to Levaquin interactions include:
- Aluminum, calcium, or magnesium antacids (Alternagel®, Gaviscon®, Maalox®, Mylanta®, Tums®, and many others)
- Certain arrhythmia medications, including:
- Amiodarone (Cordarone®, Pacerone®)
- Quinidine
- Procainamide (Procanbid®)
- Sotalol (Betapace®)
- Corticosteroids, such as:
- Betamethasone (Celestone®)
- Cortisone
- Dexamethasone (Decadron®)
- Fludrocortisone (Florinef®)
- Hydrocortisone (Cortef®)
- Methylprednisolone (Depo-Medrol®, Medrol®)
- Prednisolone (Ovapred®, Pediapred®)
- Prednisone
- Triamcinolone (Kenalog®, Aristospan®)
- Diabetes medications
- Didanosine (Videx®)
- Nonsteroidal anti-inflammatory drugs (NSAIDs), such as:
- Ibuprofen (Motrin®, Advil®)
- Naproxen (Naprosyn®) or naproxen sodium (Aleve®, Anaprox®, Naprelan®)
- Diclofenac (Cataflam®, Voltaren®)
- Indomethacin (Indocin®)
- Nabumetone (Relafen®)
- Oxaprozin (Daypro®)
- Celecoxib (Celebrex®)
- Meloxicam (Mobic®)
- Etodolac (Lodine®)
- Ketoprofen (Orudis®)
- Ketorolac (Toradol®)
- Oral typhoid vaccine
- Quinapril (Accupril®) or quinapril-HCTZ (Accuretic®)
- Sevelamer (Renagel®, Renvela®)
- Sucralfate (Carafate®)
- Theophylline (Uniphyl®, Theocron®, TheoCap®, Theo-24®, Elixophyllin®)
- Vitamins that contain aluminum, calcium, magnesium, zinc, or iron
- Warfarin (Coumadin®, Jantoven®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD