Antibiotics Home > Augmentin Drug Interactions

If birth control pills, methotrexate, or an oral typhoid vaccine is taken in conjunction with Augmentin, drug interactions could develop. These negative interactions may increase your risk of side effects, reduce the effectiveness of the medications, or lead to high drug levels in your system. To help prevent Augmentin drug interactions, talk to your healthcare provider before taking any other medicines.

An Overview of Augmentin Drug Interactions

Augmentin® (amoxicillin and clavulanate potassium) can potentially interact with several other medicines. Some of the medicines that may lead to Augmentin drug interactions include:

Augmentin Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Augmentin is combined with any of the drugs listed above.
Combining allopurinol with antibiotics similar to Augmentin increases the risk of skin rashes. It is not known whether this is also true with Augmentin.
Penicillin-type antibiotics (including Augmentin) may decrease the body's ability to remove methotrexate, leading to high blood levels of methotrexate in the blood. Your healthcare provider may need to monitor your more closely to prevent this interaction from occurring.
Oral Anticoagulants
There have been rare reports of Augmentin interacting with oral anticoagulants such as warfarin, causing a high international normalized ratio (INR), which may indicate an increased risk for bleeding. Your healthcare provider may need to monitor you more closely if you must take these two medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
List of references (click here):
Other Articles in This eMedTV Presentation

Topics & Medications


Related Channels

eMedTV Links
Copyright © 2006-2019 Clinaero, Inc.

eMedTV serves only as an informational resource. This site does not dispense medical advice or advice of any kind. Site users seeking medical advice about their specific situation should consult with their own physician. Click Terms of Use for more information.

This site complies with the HONcode standard for trustworthy health information:
verify here.