Azactam is a medication licensed for the treatment of various infections, including those that affect the urinary tract, lower respiratory tract, and skin. This antibiotic works by preventing bacteria from growing and multiplying. It is injected into a vein or muscle every 6 to 12 hours. Side effects are possible and include nausea, vomiting, and diarrhea.
What Is Azactam?
Azactam® (aztreonam injection) is a prescription antibiotic approved to treat a wide variety of infections, including infections of the urinary tract, lower respiratory tract, skin, abdomen (stomach), and pelvis. It is also used to manage infections that occur after surgery. It belongs to a class of antibiotics called monobactams.
Azactam is only effective against infections that are caused by bacteria classified as Gram-negative bacteria. Gram-negative bacteria include Escherichia coli (E. coli), Pseudomonas aeruginosa, Klebsiella, and several others.
The antibiotic contained in Azactam is also available in an inhaled form -- Aztreonam for inhalation (Cayston®). This form is approved to treat people with cystic fibrosis who have a chronic lung infection due to the bacterium Pseudomonas aeruginosa.
Azactam comes in two forms -- as a powder that must be mixed with an appropriate liquid and as a premixed solution. Azactam powder for injection is made by Bristol Myers Squib Company. Azactam premixed solution is made by Baxter Healthcare Corporation for Bristol Myers Squib Company.
How Does Azactam Work?
Azactam is an antibiotic medicine that works by killing bacteria. It does this by preventing the bacteria from making their cell walls. Because bacteria need their cell walls to survive, this causes the bacteria to die.
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed June 28, 2013.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed June 28, 2013.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
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