Antibiotics Home > Cefazolin Side Effects

As an older medication, cefazolin has not been extensively researched for possible side effects and how often they might occur. However, based on the available information, some of the possible reactions may include diarrhea, nausea, and vomiting. Notify your healthcare provider immediately if you develop anything that just doesn't seem right while using this antibiotic.

An Introduction to Side Effects of Cefazolin

Just like any medicine, cefazolin (Ancef®) can cause side effects. However, not everyone who receives the drug will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with cefazolin. Your healthcare provider can discuss a more complete list with you.)

Cefazolin Side Effects to Report

Some side effects of cefazolin are potentially serious and should be reported immediately to your healthcare provider. These include but are not limited to:
  • Signs of an overdose, which can occur even with regular doses if a person has less-than-normal kidney function, such as:
    • Seizures
    • Coma
    • Unusual muscle movements or hyperactivity
  • Watery or bloody diarrhea, which may start while using the drug or even quite a while after treatment ends
  • Signs of an allergic reaction, such as:
    • An unexplained rash
    • Itching
    • Hives
    • Redness of the face
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
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