Antibiotics Home > Drug Interactions With Cefazolin

If you are taking birth control pills, warfarin, or certain antibiotics, talk to your healthcare provider about whether these products might cause drug interactions with cefazolin. Some of these reactions may lead to a decreased effectiveness of the medicine or increase your risk for side effects, among other things. To reduce your risk for complications, tell your healthcare provider about all medications, vitamins, and supplements you are taking.

An Overview of Cefazolin Interactions

Cefazolin (Ancef®) may react with a few other products. Some of the drugs that can interact with cefazolin include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

More Detail on Drug Interactions With Cefazolin

The following sections explain in detail the potentially negative interactions that can occur when cefazolin is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining cefazolin with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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