Antibiotics Home > Cefzil Drug Interactions

Taking Cefzil may lead to problems when combined with birth control pills, aminoglycoside antibiotics, or certain other products. When these drugs are taken together, it may lead to an increased risk for side effects or other problems. You can reduce your risk for interactions by telling your healthcare provider about all medications, vitamins, and supplements you are taking.

An Overview of Interactions With Cefzil

Cefzil® (cefprozil) may react with a few other products. Some of the drugs that can interact with Cefzil include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

Cefzil Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Cefzil is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining Cefzil with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while taking Cefzil (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
Oral Typhoid Vaccine
Like other antibiotics, Cefzil may decrease the effectiveness of the oral typhoid vaccine. If you have received Cefzil recently, or are currently using this medication, your oral typhoid vaccine may need to be postponed for at least a day after receiving it.
Probenecid can decrease the body's ability to remove Cefzil from the blood, potentially leading to high Cefzil blood levels. Talk with your healthcare provider before using these medications together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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