Antibiotics Home > Drug Interactions With Cleocin

Several medications can cause negative drug interactions with Cleocin, including erythromycin, neuromuscular-blocking medications, and the oral typhoid vaccine. These interactions could decrease the effectiveness of the medications or increase the risk of side effects. To ensure a safe treatment process with Cleocin, tell your healthcare provider about any other drugs you are taking, including nonprescription medications.

Does Cleocin Interact With Other Drugs?

Cleocin® (clindamycin) can potentially interact with a few other medications. Some of the drugs that may lead to interactions with Cleocin include but are not limited to:
  • Erythromycin (Ery-Tab®, E.E.S®)
  • Neuromuscular-blocking medications, such as:
    • Atracurium
    • Cisatracurium (Nimbex®)
    • Pancuronium
    • Rocuronium (Zemuron®)
    • Succinylcholine (Anectine®, Quelicin®)
    • Vecuronium (Norcuron®)

Cleocin Drug Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Cleocin is combined with any of the drugs listed above.
Cleocin can make erythromycin less effective. In general, these medications should not be combined, especially when treating serious infections.
Neuromuscular-Blocking Medications
Cleocin has neuromuscular-blocking activity and might increase the risk of problems if combined with other neuromuscular-blocking medications. Such medications are typically used during general anesthesia or when a breathing tube is needed in an intensive care unit (ICU).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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