Antibiotics Home > Dicloxacillin Drug Interactions
Certain complications may occur in people who take dicloxacillin with products like tetracycline antibiotics, oral typhoid vaccine, or birth control pills. Some of these drug interactions with dicloxacillin may increase the risk for side effects or make the medications less effective. To help avoid these and other problems, let your healthcare provider know about all other medications, vitamins, or supplements you are taking.
Dicloxacillin may react with a number of other products. Some of the drugs that can interact with dicloxacillin include but are not limited to:
- Oral typhoid vaccine
- Probenecid (Benuryl™)
- Tetracycline antibiotics, such as:
The following sections explain in detail the potentially negative interactions that can occur when dicloxacillin is combined with any of the drugs listed above.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking oral contraceptives. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while taking dicloxacillin (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
Oral Typhoid Vaccine
Like other antibiotics, dicloxacillin may decrease the effectiveness of the oral typhoid vaccine. If you have taken dicloxacillin recently, or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking this medication.
Probenecid can decrease the body's ability to remove dicloxacillin from the blood, potentially leading to high dicloxacillin blood levels. Talk with your healthcare provider before taking these medications together. In some cases, probenecid is used in combination with dicloxacillin intentionally to make the antibiotic more effective; however, this must be done very carefully.
Tetracycline antibiotics can make dicloxacillin less effective. In general, these drugs should not be used together.
Dicloxacillin can make warfarin less effective. Check with your healthcare provider before taking these medications together. More frequent monitoring, along with warfarin dosage adjustments, may be necessary.