Antibiotics Home > What You Need to Know About Factive and Tendon Problems

Do Some People Have a Higher Risk for Tendon Ruptures With Factive?

Tendon rupture can occur in anyone who takes Factive. However, some people appear to have a higher risk. This includes people who:
  • Are over 60 years of age
  • Take corticosteroid medications (see Factive Drug Interactions)
  • Have had kidney, heart, or lung transplants
  • Engage in strenuous physical activity
  • Have kidney failure (renal failure)
  • Have a history of tendon problems, such as rheumatoid arthritis.
Tendon problems have also been reported in people who did not seem to have any of the risks listed above.

Signs of Tendon Problems

If you are taking Factive (or other quinolones), be watchful for any signs of tendonitis or tendon rupture, including:
  • Tendon pain, swelling, or inflammation
  • A snapping or popping sound, followed by sharp pain in a tendon area
  • Immediate bruising after an injury to a tendon area
  • Weakness
  • Difficulty moving joints or walking.
Most tendon problems with fluoroquinolones, including Factive, occur about eight days after starting treatment. However, problems can happen as early as within two hours after the first dose, or as late as six months after treatment has stopped.

Talking to Your Healthcare Provider

If you have any of the risks listed above, talk to your healthcare provider about possible tendon problems before you begin Factive treatment. If you develop signs of tendon problems, or experience a ruptured tendon while taking Factive, stop the medication and contact your healthcare provider immediately. Do not exercise or use the affected area until your healthcare provider makes sure you do not have a ruptured tendon.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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