Antibiotics Home > Taking Factive With Other Drugs
Factive Drug Interactions ExplainedThe following sections explain in detail the potentially negative reactions that can occur when Factive is combined with any of the drugs listed above.
Aluminum, Calcium, or Magnesium Antacids
Aluminum, calcium, and magnesium can bind to Factive in the digestive tract, preventing it from being fully absorbed into the bloodstream. You should not take any aluminum or magnesium products within three hours before or two hours after a dose of Factive. Calcium appears to have less of an effect than aluminum or magnesium; however, it is still probably a good idea to avoid taking calcium and Factive at the same time, as a precaution.
Taking Factive with corticosteroids may increase your risk for tendon problems, such as tendonitis or tendon rupture. Older adults who take corticosteroids appear to have a greater risk for this reaction. If you take Factive with a corticosteroid, make sure to watch for any signs of tendon problems, such as tendon or joint pain or tenderness (see Factive and Tendon Rupture for more information).
Some forms of didanosine can bind to Factive in the digestive tract, preventing it from being completely absorbed into the bloodstream. This interaction pertains only to the chewable tablet and liquid forms of didanosine. Do not take didanosine chewable tablets or liquid within three hours before or two hours after a dose of Factive.
In general, Factive should be used with caution with any other medication that may cause QT prolongation (a certain change in the heart rhythm). Taking Factive with these medications may increase the risk of a life-threatening arrhythmia. Talk to your healthcare provider about this interaction if you take any QT-prolonging medications.