It is "common knowledge" that alcohol and Flagyl interact in a severe or even dangerous way. Even the prescribing information for Flagyl warns of the possible interaction, stating that consuming alcohol while taking Flagyl (or even within three days of taking Flagyl) may cause the following side effects:
However, recent clinical studies have failed to demonstrate a significant interaction between Flagyl and alcohol. Despite the lack of a demonstrated interaction between alcohol and Flagyl, your healthcare provider and pharmacist will probably still warn you to avoid alcohol while taking Flagyl. This is probably a good idea, although for other reasons than the presumed interaction (such as because it is not wise to drink alcohol while recovering from an infection). Most of the supposed effects of the Flagyl/alcohol interaction can be attributed to the medication itself.
Combining Flagyl with amprenavir oral solution (but not the other forms of amprenavir) can interact dangerously with Flagyl. These medications should not be taken together.
Certain Seizure Medications
Certain seizure medications may decrease the level of Flagyl in your blood, perhaps making it less effective. Check with your healthcare provider before combining Flagyl with a seizure medication.
Cimetidine may increase the level of Flagyl in your blood, perhaps increasing your risk of Flagyl side effects. Check with your healthcare provider before taking cimetidine with Flagyl.
Taking Flagyl and disulfiram together can cause psychosis (such as hallucinations). You should not take Flagyl if you have taken disulfiram within the past two weeks.
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