A long-acting drug, Macrobid® (nitrofurantoin monohydrate/macrocrystalline) is an antibiotic used to treat bladder infections. It comes in the form of a capsule and is taken twice a day. The typical course of treatment lasts seven days. Although most people tolerate the medicine well, side effects are possible; common problems reported with this product include headache, flatulence, and nausea.
Macrobid works in a unique way, compared to other antibiotics. In bacterial cells, the medication is changed into a highly reactive form that destroys certain bacterial proteins and molecules. As a result, it interferes with bacteria's ability to make protein, DNA, and other essential cell components.
It's important to review the drug safety information on Macrobid before starting treatment. This medication may not be the best choice in all cases, so tell your healthcare provider if you have any other medical conditions (such as diabetes or anemia) or are taking any medications, including prescription and nonprescription drugs, vitamins, and herbal supplements.
(For more information on this drug, click Macrobid. This article takes an in-depth look at the product's uses, dosing guidelines, warnings, and more.)
Written by/reviewed by: Kristi Monson, PharmD;Arthur Schoenstadt, MD
Food and Drug Administration, Center for Drug Evaluation and Research. Electronic orange book: approved drug products with therapeutic equivalence evaluations. FDA Web site. Available at: http://www.fda.gov/cder/ob/. Accessed November 3, 2009.
Briggs GG, Freeman RK, Yaffe SJ. Drugs in Pregnancy and Lactation. 8th ed. Philadelphia (PA): Lippincott Williams & Wilkins;2008.
National Library of Medicine (US). Drugs and Lactation Database (LactMED). NLM Web site. Available at: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT. Accessed November 3, 2009.
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