Antibiotics Home > Macrobid Drug Interactions

Some of the drugs that can interact with Macrobid include oral typhoid vaccine, antacids containing magnesium trisilicate, and Probenecid. Drug interactions with this product can lead to problems such as not being able to fully absorb Macrobid. To reduce your risk of problems, tell your healthcare provider about any other medications you are taking.

An Overview of Interactions With Macrobid

Macrobid® (nitrofurantoin monohydrate/macrocrystalline) can potentially interact with a number of other medicines. The medications that can cause Macrobid drug interactions include but are not limited to:

More Information on Macrobid Drug Interactions

The following sections explain in detail the potentially negative interactions that can occur when Macrobid is taken with any of the drugs listed above.
Magnesium Trisilicate
If Macrobid is taken with products containing magnesium trisilicate, your body may not absorb Macrobid adequately. These medications should not be combined.
Macrobid may make norfloxacin less effective. In general, these medications should not be taken together.
Oral Typhoid Vaccine
Macrobid could decrease the effectiveness of the oral typhoid vaccine. If you are taking Macrobid, your oral typhoid vaccine may need to be postponed for at least a day after finishing your Macrobid prescription.
Probenecid can affect the way the kidneys handle Macrobid. This can cause Macrobid to build up in the bloodstream, possibly leading to toxicity, and may also make Macrobid less effective. Talk to your healthcare provider before taking these medicine together.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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