Antibiotics Home > Oxacillin Dosage

Oxacillin is given as an injection into a vein (by IV) or a muscle (IM injection) every four to six hours. The oxacillin dosage your healthcare provider recommends will depend on your age, the type and severity of the infection, and various other factors. Treatment will usually continue for at least two days after signs of the infection are gone.

An Introduction to Dosing With Oxacillin

The dose of oxacillin your healthcare provider recommends will vary, depending on factors such as:
  • Your age
  • Your weight
  • The type and severity of the infection being treated
  • Other medical conditions you may have.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.

What Is the Recommended Oxacillin Dosage for Adults?

The standard dose of oxacillin for treating mild-to-moderate infections in adults is 250 mg to 500 mg every 4 to 6 hours given intravenously (by IV) or intramuscularly (IM injection). For severe infections, a higher dosage of 1 gram (1000 mg) every 4 to 6 hours given by IV or IM is used.

Oxacillin Dosing Guidelines for Children

The standard recommended dose of oxacillin for children will vary, depending mostly on the child's weight and the severity of the infection. In general, the standard amount for treating mild-to-moderate infections is 50 mg per kg (about 22.7 mg per lb) every 6 hours given by IV or intramuscular injection. For more serious infections, the standard dose is 100 mg per kg (about 45.5 mg per lb) every 4 to 6 hours by IV or IM.
For premature babies and newborns, the recommended dosage is a total of 25 mg per kg per day (about 11.4 mg per lb).

General Information on Using Oxacillin

Some considerations to keep in mind during treatment with oxacillin include the following:
  • This medication is given by IV or injected into a muscle every four to six hours.
  • The length of treatment recommended will vary, depending on the type and severity of the infection. Usually, treatment is continued for at least two days after all signs and symptoms of the infection are gone.
  • Make sure to finish the prescribed course of this antibiotic, as stopping it too soon can lead to a more serious infection.
  • If you are unsure about anything related to your dosage or oxacillin dosing in general, please talk to your healthcare provider or pharmacist.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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