Antibiotics Home > Oxacillin Drug Interactions

A number of problems can occur in people who combine oxacillin with products like birth control pills, probenecid, or various antibiotics. Some of these drug interactions with oxacillin may increase or decrease the effectiveness of the medications. To help ensure a safe treatment, let your healthcare provider know about all other medications, vitamins, or supplements you are taking.

An Overview of Interactions With Oxacillin

Oxacillin may react with a number of other products. Some of the drugs that can interact with oxacillin include but are not limited to:

Oxacillin Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when oxacillin is combined with any of the drugs listed above.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while using oxacillin (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
Oral Typhoid Vaccine
Like other antibiotics, oxacillin may decrease the effectiveness of the oral typhoid vaccine. If you have received oxacillin recently, or are currently using it, your oral typhoid vaccine may need to be postponed for at least a day after receiving oxacillin.
Probenecid can decrease the body's ability to remove oxacillin from the blood, potentially leading to high oxacillin blood levels. Talk with your healthcare provider before using these medications together. In some cases, probenecid is used in combination with oxacillin intentionally to make the antibiotic more effective; however, this must be done very carefully.
Tetracycline Antibiotics
Tetracycline antibiotics can make oxacillin less effective. Check with your healthcare provider before using oxacillin with a tetracycline antibiotic.
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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