Antibiotics Home > Oxacillin Warnings and Precautions

Oxacillin may cause potentially serious complications like allergic reactions, serious side effects, or bloody diarrhea for some people. People who have kidney disease should talk to their healthcare provider before using oxacillin. Other safety precautions include warnings for people who have a penicillin allergy and those who are taking certain medications.

What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to receiving oxacillin if you have:
  • Kidney disease, such as kidney failure (renal failure)
  • An allergy to penicillin or penicillin antibiotics
  • Any other allergies, including to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.

Specific Precautions and Warnings for Oxacillin

Some warnings and precautions to be aware of prior to using this drug include the following:
  • Oxacillin is an antibiotic that belongs to the penicillin group of antibiotics. People can be severely allergic to penicillin. Do not take this medication if you are allergic to penicillin medications. Because an allergic reaction to oxacillin can be extremely dangerous, let your healthcare provider know immediately if you notice any signs of an allergic reaction, such as:
    • A rash
    • Itching
    • Hives
    • Wheezing
    • Swelling of the mouth or lips
    • Difficulty breathing.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of oxacillin, bloody or watery diarrhea may be a sign of a serious reaction to oxacillin that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop taking oxacillin and can be life-threatening.
  • Antibiotics, including oxacillin, can sometimes cause yeast infections, as they can get rid of "good" bacteria that help protect against yeast infections. Let your healthcare provider know if you develop a vaginal yeast infection or thrush (a yeast infection of the mouth) during treatment.
  • Oxacillin should not be used to treat viruses, such as the common cold or the flu. Oxacillin is completely ineffective for treating viruses, and such use can lead to bacterial resistance to oxacillin.
  • Oxacillin is a pregnancy Category B medication. This means it is probably safe for use during pregnancy, although the full risks are currently unknown. Talk to your healthcare provider about the risks and benefits of using oxacillin during pregnancy (see Oxacillin and Pregnancy for more information).
  • Oxacillin passes through breast milk. Therefore, if you are breastfeeding or plan to start, make sure to talk with your healthcare provider about this before using oxacillin (see Oxacillin and Breastfeeding for more information).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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