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Plaquenil Interactions Explained

The following sections explain in detail the potentially negative interactions that can occur when Plaquenil is combined with any of the drugs listed above.
 
Certain Beta Blockers
Plaquenil may increase the level of some (but not all) beta blockers in the blood, perhaps increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
Certain Parasite Medications
Plaquenil may decrease the level of some parasite medications in the blood, possibly making them less effective. Check with your healthcare provider before taking these medications together.
 
Cyclosporine
Plaquenil may increase the level of cyclosporine in your blood, which can be quite dangerous. If you take these two medications together, your healthcare provider may need to monitor your cyclosporine levels and adjust your cyclosporine dosage as necessary.
 
Digoxin
Plaquenil may increase the level of digoxin in your blood, which can be quite dangerous. If you take these two medications together, your healthcare provider may need to monitor your digoxin levels and adjust your digoxin dosage as necessary.
 
Mefloquine
Plaquenil and mefloquine should not be combined, as this increases the risk of dangerous problems such as seizures or irregular heart rhythms (arrhythmias). If your healthcare provider recommends switching from Plaquenil to mefloquine, you should wait at least 12 hours after your last dose of Plaquenil before taking mefloquine.
 
Phenothiazines
Plaquenil may increase the level of phenothiazine medications in the blood, perhaps increasing the risk of side effects. Check with your healthcare provider before taking these medications together.
 
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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