Antibiotics Home > Septra Drug Interactions

If tricyclic antidepressants, oral diabetes medications, or certain other drugs are taken together with Septra, drug interactions may occur. Some interactions with the antibiotic can increase your risk for potentially serious side effects, while others may reduce the effectiveness of the medicines. Other drugs that may cause Septra interactions include thiazide diuretics, ACE inhibitors, cyclosporine, and indomethacin.

An Overview of Septra Interactions

Septra® (sulfamethoxazole/trimethoprim) can potentially interact with many medications, too many to list entirely in this article. Some (but not all) of these medicines that may lead to Septra drug interactions include:
  • Angiotensin-converting enzyme inhibitors (usually known as ACE inhibitors), including:









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Last reviewed by: Kristi Monson, PharmD;
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