Antibiotics Home > Septra Side Effects

Allergic skin reactions, nausea, and loss of appetite are the most common side effects reported with Septra. Side effect information for this medication is very vague, as the drug was approved long before manufacturers were required to provide detailed information about possible side effects. Some of the side effects that may require medical attention include shortness of breath, fatigue, and decreased urination.

An Introduction to Septra Side Effects

As with any medicine, side effects are possible with Septra® (sulfamethoxazole/trimethoprim). However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
(This article covers many, but not all, of the possible side effects with Septra. Your healthcare provider can discuss a more complete list of Septra side effects with you.)

Common Side Effects of Septra

Septra was approved long before the United States Food and Drug Administration required manufacturers to include highly detailed information about side effects in the prescribing information for the medications. Therefore, only vague side effect information is available for this medicine; the exact percentages of individual side effects are not provided in the Septra prescribing information.
Based on this limited information, the most common Septra side effects include:
  • Loss of appetite
  • Nausea, with or without vomiting
  • Allergic skin reactions (such as a rash or itching).
Even though a skin rash due to Septra is quite common, it should always be reported to your healthcare provider. In general, it is recommended that you stop taking Septra at the first sign of a skin rash, as very dangerous reactions can develop (although this happens only rarely).
Written by/reviewed by:
Last reviewed by: Kristi Monson, PharmD;
Last updated/reviewed:
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