Antibiotics Home > Learning More About Sulfatrim's Indications
How Does It Work?Sulfatrim contains two different antibiotics, sulfamethoxazole and trimethoprim. Combining sulfamethoxazole with trimethoprim increases the effectiveness of the drugs and decreases the chance of antibiotic resistance (the development of bacteria with the ability to resist antibiotics).
While trimethoprim does not belong to a specific class of medications, sulfamethoxazole belongs to a group of drugs known as sulfonamides ("sulfa" drugs). These two antibiotics work in different but similar ways. Essentially, both sulfamethoxazole and trimethoprim work by inhibiting the production of folic acid in bacteria, although they work in different stages of folic acid production. Folic acid is important for making proteins and DNA. Because humans obtain folic acid from the diet (and bacteria cannot), human cells are less affected by Sulfatrim.