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Metronidazole Drug Interactions
If you take disulfiram, cimetidine, or certain other medications with metronidazole, drug interactions could occur. These interactions can reduce the effectiveness of the medicines or increase your risk for potentially dangerous side effects. In order to help minimize your risk of developing these and other problems, tell your healthcare provider about all other medications you are taking.
Metronidazole (Flagyl®, MetroCream®, MetroGel®, MetroGel-Vaginal®, MetroLotion®, Noritate®, Vandazole®) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with metronidazole include but are not limited to:
- Alcohol
- Amprenavir oral solution (Agenerase®)
- Certain seizure medications, such as:
- Cimetidine (Tagamet®)
- Disulfiram (Antabuse®)
- Eplerenone (Inspra™)
- Lithium (Eskalith®, Lithobid®)
- Maraviroc (Selzentry™)
- Oral typhoid vaccine
- Ranolazine (Ranexa®)
- Warfarin (Coumadin®, Jantoven®).
Metronidazole Drug Interactions Explained
The following sections explain in detail the potentially negative interactions that can occur when metronidazole is combined with any of the drugs listed above.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD