Minocycline Drug Interactions (Cont.)

 
Retinoic Acid Derivatives
If minocycline and retinoic acid derivatives or retinoic acid are taken together, you may be at increased risk for developing a condition known as pseudotumor cerebri (increased pressure inside the brain). Common symptoms of this condition include headaches, nausea, or vomiting.
 
Aluminum/Calcium/Magnesium/Iron Products
If you are taking both minocycline and products or foods containing aluminum, calcium, magnesium, or iron, your body may metabolize these things differently than intended. You can prevent this interaction by taking these products either two hours before or two hours after you take your minocycline dose.
 
Sodium Bicarbonate
If minocycline and sodium bicarbonate (an antacid) are combined, your body may metabolize the two differently than intended, which can significantly decrease the amount of minocycline in your system. To prevent this interaction, your healthcare provider may choose to monitor your progress more closely and adjust your dose.
 
Bismuth Subsalicylate
When minocycline and Pepto Bismol are taken together, your body may metabolize them differently than intended. This can significantly decrease the amount of minocycline in your system. Your healthcare provider may choose to monitor your progress and adjust your dose accordingly, depending on your individual situation.
 
Quinapril
If minocycline and quinapril are combined, your body may metabolize the drugs differently than intended and significantly decrease the amount of minocycline in your system. To prevent this, your healthcare provider may choose to monitor your progress more closely and adjust your dosages.
 
Penicillin and Cephalosporins
If you are taking minocycline, it is recommended that you do not take cephalosporins or penicillin at the same time (both cephalosporins and pencillin are types of antibiotics). The minocycline may reduce the ability of cephalosporins and pencillin to fight infections. Alternate options should be discussed with your healthcare provider.
(Minocycline Drug Interactions Continued: Page 3)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;