Minocycline Drug Interactions

When certain medicines are taken with minocycline, drug interactions that could result in side effects or serious complications may occur. Medicines that can cause interactions with minocycline include oral contraceptives, cimetidine, penicillin, and retinoids. Aside from causing unwanted side effects, these minocycline drug interactions could cause one or both medications to lose their effectiveness.

Minocycline Drug Interactions: An Introduction

Minocycline can potentially interact with a number of medicines. These minocycline drug interactions can include but are not limited to:
 
 
 
  • Oral typhoid vaccine
  • Penicillins, such as:
     
    • Amoxicillin (Amoxil®, Moxatag®)
    • Amoxicillin and clavulanate potassium (Augmentin®, Augmentin ES-600®, Augmentin XR®)
    • Ampicillin
    • Ampicillin and sulbactam (Unasyn®)
    • Carbenicillin (Geocillin®)
    • Dicloxacillin
    • Nafcillin
    • Oxacillin
    • Penicillin (Bicillin® C-R, Bicillin® L-A, Pfizerpen®)
    • Piperacillin
    • Piperacillin and tazobactam (Zosyn®)
    • Ticarcillin and clavulanate potassium (Timentin®)
 
  • Quinapril (Accupril®)
  • Retinoids, such as:
     
    • Acitretin (Soriatane®)
    • Bexarotene (Targretin®)
    • Isotretinoin (Accutane®, Amnesteem™, Claravis™, Sotret®)
    • Tretinoin (Atralin™, Avita®, Renova®, Retin-A®, Tretin-X™, Vesanoid®)
    • Tazarotene (Avage™, Tazorac®)
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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