Minocycline Precautions and Warnings

Before taking minocycline, precautions and warnings for the drug should be reviewed to minimize the risk of side effects and to ensure a safe treatment process. People who should avoid minocycline include people who are allergic to the drug and those who have liver or kidney failure, among others. Minocycline precautions and warnings also extend to possible side effects, such as skin reaction, lightheadedness, or dizziness.

Minocycline: What Should I Tell My Healthcare Provider?

You should talk to your healthcare provider prior to taking minocycline if you have:
  • Frequent yeast infections
  • Liver disease or liver failure
  • Kidney disease such as kidney failure (renal failure)
  • Any other allergies, including allergies to food, dyes, or preservatives.

Also, let your healthcare provider know if you are:


  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Be sure to tell your healthcare provider about all other medicines you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Minocycline Precautions and Warnings

Precautions and warnings to be aware of prior to taking minocycline include the following:
  • Minocycline may cause permanent discoloration of teeth in infants and young children. In most situations, this antibiotic should be avoided in children under the age of eight years old and during pregnancy.
  • Minocycline is considered a pregnancy Category D medicine. This means that there is significant risk to an unborn baby. If you are pregnant, discuss these risks with your healthcare provider before using minocycline (see Minocycline and Pregnancy for more information).
  • To avoid damage to the esophagus while taking minocycline, make sure to take the medication with plenty of fluids. Do not take this medication lying down, and do not lie down immediately after taking this medication. These measures are necessary to make sure that the minocycline tablet does not accidentally stick in your throat, where it could cause significant irritation and damage.
  • Let your healthcare provider know if you experience bloody or watery diarrhea. While diarrhea is a common side effect of antibiotics, bloody or watery diarrhea may be a sign of a serious reaction to antibiotics that can occur when certain bacteria (Clostridium difficile) overgrow in the colon. This severe reaction can occur long after you stop taking the antibiotic and can be quite dangerous.
  • If you have kidney disease or severe liver disease, your healthcare provider may choose to give you a lower dose than normal or not prescribe the drug at all.
  • Minocycline may cause pseudotumor cerebri, which is a condition that causes high pressures inside the brain. This condition commonly causes headaches, blurred vision, nausea, vomiting, and dizziness. In most cases, the symptoms improve when minocycline is stopped.
  • While taking antibiotics such as minocycline, other infections have been known to occur (for example, vaginal yeast infections). If you notice symptoms unrelated to your original condition, talk to your healthcare provider.
  • Skin reactions that resemble serious sunburns may occur if you are exposed to sunlight while taking minocycline. Try to avoid unnecessary sunlight exposure while taking this antibiotic. If sunlight exposure is unavoidable, cover as much of your skin as possible (long sleeves, long pants, and a hat), and use a sunscreen with a rating of SPF 45 or higher.
  • Some people on minocycline may experience lightheadedness, dizziness, or a spinning sensation (vertigo). If you experience any of these symptoms, you should not drive or operate heavy machinery.

Minocycline HCL

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