Nafcillin Drug Interactions

Nafcillin Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when nafcillin is combined with any of the drugs listed above.
 
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
 
Ask your healthcare provider about whether you need to use a backup method of birth control while using nafcillin (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
 
CYP 3A4 Substrates
Nafcillin slows down the activity of a liver enzyme known as CYP 3A4. This enzyme is responsible for breaking down (metabolizing) many drugs; these drugs that are broken down by CYP 3A4 are known as CYP 3A4 substrates. Therefore, nafcillin may increase the level of CYP 3A4 drugs.
 
For some CYP 3A4 substrates, this interaction may not be important. However, for many CYP 3A4 substrates, particularly those listed above, a potentially serious interaction may result. In general, nafcillin should not be combined with these medications, especially if other alternatives to nafcillin are available.
 
Oral Typhoid Vaccine
Like other antibiotics, nafcillin may decrease the effectiveness of the oral typhoid vaccine. If you have received nafcillin recently, or are currently using it, your oral typhoid vaccine may need to be postponed for at least a day after receiving nafcillin.
 
Probenecid
Probenecid can decrease the body's ability to remove nafcillin from the blood, potentially leading to high nafcillin blood levels. Talk with your healthcare provider before using these medications together. In some cases, probenecid is used in combination with nafcillin intentionally to make the antibiotic more effective; however, this must be done very carefully.
 
Tetracycline Antibiotics
Tetracycline antibiotics can make nafcillin less effective. Check with your healthcare provider before using nafcillin with a tetracycline antibiotic.
 
Warfarin
Nafcillin can make warfarin less effective. Close monitoring, along with warfarin dosage adjustments, may be necessary.
 

Nafcillin Antibiotic Information

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