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Drug Interactions With Rocephin
Medicines that can interact with Rocephin include warfarin, probenecid, and sulfinpyrazone. These interactions can significantly increase the amount of Rocephin in your body. If drug interactions with Rocephin occur, your healthcare provider may choose to monitor your progress more closely and adjust your Rocephin dosage.
Rocephin® (ceftriaxone) can interact with a number of medicines. Drugs that can interact with Rocephin include, but are not limited to, the following:
- Calcium or calcium-containing products
- Warfarin (Coumadin®, Jantoven®)
- Probenecid (Benemid®, Probalan®)
- Sulfinpyrazone (Anturane®).
The following sections explain in detail the potentially negative interactions that can occur when Rocephin is combined with any of the drugs listed above.
Calcium or Calcium-Containing Products
Calcium and calcium-containing products can bind to Rocephin and cause dangerous deposits in the lungs and kidneys. This is most likely to occur in newborns. Therefore, Rocephin should never be given to newborns who must also receive a calcium-containing IV product (even if the medications are given at different times).
For any other age group, such calcium IV products can be given, as long as they are not mixed with Rocephin or given at the same time. The IV must be thoroughly flushed between Rocephin and calcium products. It is important to be aware that many different IV medications contain calcium.
If you are taking Rocephin and warfarin, your body may metabolize the drugs differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests that measure how well your blood clots.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD