Antibiotics
Medications
Related eMedTV
Health Channels

Drug Interactions With Rocephin

Medicines that can interact with Rocephin include warfarin, probenecid, and sulfinpyrazone. These interactions can significantly increase the amount of Rocephin in your body. If drug interactions with Rocephin occur, your healthcare provider may choose to monitor your progress more closely and adjust your Rocephin dosage.

 

Rocephin Drug Interactions: An Introduction

Rocephin® (ceftriaxone) can interact with a number of medicines. Drugs that can interact with Rocephin include, but are not limited to, the following:
 
  • Calcium or calcium-containing products
  • Warfarin (Coumadin®, Jantoven®)
  • Probenecid (Benemid®, Probalan®)
  • Sulfinpyrazone (Anturane®).
     

More Detail About Rocephin Interactions

The following sections explain in detail the potentially negative interactions that can occur when Rocephin is combined with any of the drugs listed above.

 
Calcium or Calcium-Containing Products
Calcium and calcium-containing products can bind to Rocephin and cause dangerous deposits in the lungs and kidneys. These products should not be taken with Rocephin or within 48 hours of stopping Rocephin. It is important to be aware that many different IV medications contain calcium.
 
Warfarin (Coumadin, Jantoven)
If you are taking Rocephin and warfarin, your body may metabolize the drugs differently than intended. You healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. INR and prothrombin time are tests that measure how well your blood clots.
(Drug Interactions With Rocephin Continued: Page 2)
Add this article to your Favorites     Email this article     Print
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;