More Products That Interfere With Septra

Leucovorin or Levoleucovorin
Leucovorin or levoleucovorin may decrease the effectiveness of Septra. In general, these medications should not be used together unless absolutely necessary.
 
Methotrexate
Septra can increase the level of methotrexate in the blood, increasing the risk of dangerous side effects of methotrexate. In general, these medications should not be used together.
 
Oral Diabetes Medications
Septra may increase the risk of low blood sugar (hypoglycemia) due to some oral diabetes medications. Check with your healthcare provider before combining Septra with an oral diabetes medication. You may need to monitor your blood sugar more closely.
 
Oral Typhoid Vaccine
Antibiotics (including Septra) may decrease the effectiveness of the oral typhoid vaccine. If you are taking Septra, your oral typhoid vaccine may need to be postponed for at least a day after your last dose of Septra.
 
Phenytoin
Septra can increase the level of phenytoin in your blood, increasing the risk of phenytoin side effects. Your healthcare provider may want to monitor the level of phenytoin in your blood and may need to adjust your phenytoin dosage.
 
Procainamide
Septra increases the level of procainamide in the blood, increasing the risk of dangerous side effects of procainamide. Check with your healthcare provider before taking these medications together.
 
Pyrimethamine
It is possible that taking Septra with pyrimethamine might increase the risk of anemia. Check with your healthcare provider before taking pyrimethamine with Septra.
 
Thiazide Diuretics
There have been reports that taking Septra with a thiazide diuretic may increase the risk of low blood platelets. Be sure to watch for any signs of low platelets, such as easy bruising or bleeding.
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