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Septra Drug Interactions
If tricyclic antidepressants, oral diabetes medications, or certain other drugs are taken together with Septra, drug interactions may occur. Some interactions with the antibiotic can increase your risk for potentially serious side effects, while others may reduce the effectiveness of the medicines. Other drugs that may cause Septra interactions include thiazide diuretics, ACE inhibitors, cyclosporine, and indomethacin.
Septra® (sulfamethoxazole/trimethoprim) can potentially interact with many medications, too many to list entirely in this article. Some (but not all) of these medicines that may lead to Septra drug interactions include:
- Angiotensin-converting enzyme inhibitors (usually known as ACE inhibitors), including:
- Benazepril (Lotensin®) or combination medications that contain benazepril (Lotensin® HCT, Lotrel®)
- Captopril (Capoten®) or combination medications that contain captopril (Capozide®)
- Enalapril (Vasotec®), or combination medications that contain enalapril (Vaseretic®, Lexxel®)
- Fosinopril (Monopril®) or combination medications that contain fosinopril (Monopril-HCT®)
- Lisinopril (Prinivil®, Zestril®) or combination medications that contain lisinopril (Prinzide®, Zestoretic®)
- Quinapril (Accupril®) or combination medications that contain quinapril (Accuretic®, Quinaretic®)
- Ramipril (Altace®)
- Amantadine (Symmetrel®)
- Angiotensin II receptor blockers (often known as ARBs), such as:
- Azilsartan (Edarbi™) or azilsartan/chlorthalidone (Edarbyclor™)
- Candesartan (Atacand®) or candesartan-hydrochlorothiazide (Atacand HCT®)
- Eprosartan (Teveten®) or eprosartan-hydrochlorothiazide (Teveten® HCT)
- Irbesartan (Avapro®) or irbesartan-hydrochlorothiazide (Avalide®)
- Losartan (Cozaar®) or losartan-hydrochlorothiazide (Hyzaar®)
- Olmesartan (Benicar®), olmesartan-hydrochlorothiazide (Benicar HCT®), or amlodipine and olmesartan (AZOR™)
- Telmisartan (Micardis®) or telmisartan-hydrochlorothiazide (Micardis® HCT)
- Valsartan (Diovan®) or valsartan-hydrochlorothiazide (Diovan HCT®)
- Cyclosporine (Gengraf®, Neoral®, Sandimmune®)
- Digoxin (Digitek®, Lanoxin®)
- Dofetilide (Tikosyn®)
- Indomethacin (Indocin®)
- Leucovorin or levoleucovorin (Fusilev™)
- Methotrexate (Rheumatrex®)
- Oral diabetes medications
- Oral typhoid vaccine
- Phenytoin (Dilantin®, Phenytek®)
- Procainamide (Procanbid®)
- Pyrimethamine (Daraprim®)
- Thiazide diuretics, such as:
- Chlorothiazide (Diuril®)
- Chlorthalidone (Thalitone®)
- Hydrochlorothiazide (Esidrix®, HydroDIURIL®, Microzide®, Oretic®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD