Sulfatrim and Pregnancy

In animal studies on Sulfatrim and pregnancy, the antibiotic increased the risk of birth defects and fetal death. However, there is only limited information available about using this drug during pregnancy in humans. If you are taking Sulfatrim and pregnancy occurs, let your healthcare provider know.

Taking Sulfatrim While Pregnant: An Introduction

Sulfatrim® (sulfamethoxazole/trimethoprim) is a prescription antibiotic often used to treat urinary tract infections (UTIs), although it is approved for several other uses as well. At this time, it is not clear if Sulfatrim is safe for use during pregnancy.

What Is Pregnancy Category D?

The U.S. Food and Drug Administration (FDA) uses a category system to classify the possible risks to a fetus when a specific medicine is taken during pregnancy. Pregnancy Category D is a classification given to medicines that have been shown to present a risk to the fetus in studies of pregnant women but may still offer benefits that outweigh the risks the drug presents. A pregnancy Category D medicine may still be given to a pregnant woman if the healthcare provider believes that the benefits to the woman outweigh the possible risks to the unborn child.
In animal studies, Sulfatrim increased the risk of cleft palate. Also, trimethoprim (one of the components of Sulfatrim) increased the risk of fetal death in rats. 
In humans, studies suggest that Sulfatrim may increase the risk of certain birth defects (like neural tube defects, heart problems, urinary tract defects, cleft palate, and club foot). Because it is thought that Sulfatrim might contribute to birth defects by decreasing folic acid, a folic acid supplement at a higher-than-normal dose for a pregnant woman might be helpful if a pregnant woman needs to take this medication.
Of possibly greater concern, Sulfatrim might increase the risk of jaundice and, theoretically, kernicterus (brain damage caused by severe jaundice) in the newborn, especially if a pregnant woman takes Sulfatrim late in pregnancy.
Pregnancy and Pain

Sulfatrim Antibiotic Information

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