Suprax Drug Interactions

There are some products that may not be safe to take in combination with Suprax, as drug interactions may occur. Some of these products include certain antibiotics, birth control pills, and the oral typhoid vaccine. Combining these medications may lead to problems such as decreased effectiveness of the products, kidney damage, or other potentially dangerous side effects.

An Overview of Interactions With Suprax

Suprax® (cefixime) may react with a few other products. Some of the drugs that can interact with Suprax include but are not limited to:
  • Aminoglycoside antibiotics, such as:
    • Amikacin (Amikin®)
    • Gentamicin
    • Kanamycin (Kantrex®)
    • Neomycin (Neo-Fradin®)
    • Streptomycin
    • Tobramycin

Suprax Drug Interactions Explained

The following sections explain in detail the potentially negative reactions that can occur when Suprax is combined with any of the drugs listed above.
Aminoglycoside Antibiotics
Combining Suprax with an aminoglycoside antibiotic may increase the risk of kidney damage. Nonetheless, in some very serious situations, such combinations may be used when the possible benefits outweigh the likely risks.
Birth Control Pills
Despite the long-standing belief that antibiotics interact with birth control pills, several studies have shown that most antibiotics do not increase the risk of pregnancy in women taking birth control pills. Nevertheless, there have been reports of birth control pill failure in women who have taken antibiotics.
Ask your healthcare provider about whether you need to use a backup method of birth control while taking Suprax (see Antibiotics and Birth Control Pills for more information). If it is very important to you to avoid pregnancy, you might consider using a backup method just to be safe.
There have been reports that Suprax may increase the levels of carbamazepine in the blood. Your healthcare provider may want to monitor your carbamazepine levels, or might decide to prescribe a different antibiotic.
Oral Typhoid Vaccine
Like other antibiotics, Suprax may decrease the effectiveness of the oral typhoid vaccine. If you have taken Suprax recently or are currently taking it, your oral typhoid vaccine may need to be postponed for at least a day after taking the drug.
Probenecid can decrease the body's ability to remove Suprax from the blood, potentially leading to high Suprax blood levels. Talk with your healthcare provider before taking these medications together.
Suprax may increase the risk of bleeding with warfarin. If these medications must be taken together, it would be a good idea for your healthcare provider to monitor your PT/INR to avoid any dangerous bleeding.
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Suprax Medication Information

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