Specific Drugs That React With Tetracycline

More Detail About Tetracycline Interactions

The following sections explain in detail the potentially negative interactions that can occur when tetracycline is combined with any of the drugs listed above.


If you are taking tetracycline with digoxin, your body may metabolize the medicines quite differently than intended. You may wish to discuss this with you healthcare provider prior to starting treatment with tetracycline.
If you are taking tetracycline and warfarin together, your body may metabolize the medicines differently than intended. Your healthcare provider may choose to monitor your INR and prothrombin time more frequently and adjust accordingly. Prothrombin time and INR are tests used to measure how well your blood is clotting.
Aluminum/Calcium/Magnesium/Iron Products
Taking both tetracycline and products or foods containing aluminum, calcium, magnesium, or iron may make the tetracycline less effective. It is a good idea to avoid taking any of the products listed above within two hours of taking your tetracycline. A few common products that contain these substances include antacids, iron or calcium supplements, multivitamins, and laxatives.
If you are taking tetracycline and happen to undergo anesthesia for a surgery or other procedure, it is possible that methoxyflurane (a general anesthetic) may be used. When tetracycline and methoxyflurane interact, severe kidney damage may occur.
Oral Contraceptives
If you are taking tetracycline and oral contraceptives, tetracycline may reduce the effectiveness of your contraceptive. Be sure to talk with your healthcare provider about alternate contraceptive options.
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Tetracycline Hydrochloride

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